A 2015 article in Therapeutics and Medical Danger Administration took a better take a look at how ibuprofen would possibly have an effect on older adults taking different drugs. Prescription ibuprofen could make angiotensin receptor blockers (ARBs) or angiotensin-converting enzyme inhibitors (ACEIs) much less efficient in treating hypertension. Some folks taking fosinopril or hydrochlorothiazide for hypertension may develop kidney failure in the event that they take excessive doses of ibuprofen. Folks taking aspirin for his or her coronary heart ought to keep away from long-term use of ibuprofen so it would not intervene with aspirin’s anticoagulant advantages.
Lengthy-term use of NSAIDs comparable to ibuprofen can enhance the danger of gastrointestinal bleeding, kidney failure, and cardiovascular issues, based on a 2010 article in The Annals of Lengthy-Time period Care. NSAIDs enhance the danger of deadly peptic ulcers, particularly in the event that they’re taken with corticosteroids and warfarin. Older adults are at the next threat of kidney failure, and this threat doubles in the event you take NSAIDs for an prolonged time. Continual use of NSAIDs also can enhance your threat of a coronary heart assault, coronary heart failure, or stroke.