The examine concerned greater than 3,400 older adults who weren’t identified with dementia earlier than the examine started. Researchers analyzed participant treatment utilization through the decade earlier than the examine by referencing pharmacy information. All through an roughly 7-year follow-up interval, somewhat over 23% of contributors developed dementia. Moreover, the analysis confirmed that over 78% of contributors had a file of at the very least one anticholinergic drug prescription within the decade previous the examine; the commonest of which have been antidepressants, bladder drugs, and antihistamines. Anticholinergic treatment use was extra generally seen amongst ladies, these with higher depressive signs, and people with comorbidities in comparison with individuals who didn’t use anticholinergics.
The examine confirmed that those that took anticholinergic medicine stood at an elevated threat for all-cause dementia, notably people who took these drugs for 3 years or longer. Whereas cognitive impairment has been a famous facet impact of anticholinergic drug utilization, it’s stated to resolve itself as soon as a affected person stops taking the treatment. Nevertheless, some consultants imagine that anticholinergics current a higher threat for such cognitive impairment persisting even after a affected person ceases taking the drug. The researchers emphasised the significance of medical professionals recognizing this potential connection and looking out into different drugs for older adults if applicable.