In line with the FDA, the CYP3A4 enzyme in your small gut sometimes breaks down your medicine. Grapefruit juice prevents this enzyme from doing its job, so extra of your medicine will get into your blood at a given time and stays there. Seville oranges, tangelos, and pomelos may additionally block this enzyme.
The research appeared on the results of each tomato juice and grapefruit juice on how two medicine are processed within the physique. Nifedipine is a calcium-channel blocker that treats hypertension, and midazolam is a sedative that slows down the nervous system. Each medicine are metabolized by the CYP3A4 enzyme. When rats got grapefruit juice earlier than taking the medicine, it considerably elevated their focus ranges within the blood. Tomato juice additionally had the identical impact on the midazolam however no impact on the nifedipine. The research means that, like grapefruit juice, tomato juice can affect how the physique handles sure medicine, however the extent of the impact might range relying on the precise drug.